Predictors of toxicity for metastatic melanoma patients treated with ipilimumab

Introduction Immunotherapy with ipilimumab, a monoclonal antibody anti-Cytotoxic T-Lymphocyte Antigen 4, demonstrated a survival advantage for metastatic melanoma patients, but the treatment is associated with immuno-related adverse events (irAEs) that may drive to severe comorbidities and challenge the treatment prosecution. No predictive factors for significant irAE (grade 3-4 according to Common Terminology Toxicity Criteria) are known. The purpose of this study was to identify prognostic factors for toxicity in melanoma patients treated with ipilimumab.